Hydrogen-bonded frameworks for conformational analysis of reactive substrates.

ABSTRACT: Guanidinium organosulfonate (GS) hydrogen-bonded host frameworks were used to trap α-halopropiophenones and α-halocyclooctanones to determine their molecular structure by single crystal X-ray diffraction. The majority of encapsulated guest molecules adopted conformations expected from computational analysis and stereochemical outcomes of Grignard reactions.

SUBMITTER: Dillon AM 

PROVIDER: S-EPMC11834950 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature