Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis.

ABSTRACT: The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in the scientific community. However, it remains to be determined whether gut microbiota directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis to explore the potential causal link between gut microbiota and CS. We initially used the inverse variance weighted method for preliminary estimation and supplemented it with other MR methods, including MR-Egger, weighted median, weighted mode, and simple mode. Furthermore, we utilized the Cochrane Q test, MR-PRESSO global test, and MR-Egger intercept test to assess possible pleiotropy and heterogeneity. Ultimately, we conducted a bidirectional M

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11835084 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature