Exploring the causal relationship between constipation and ileus: Insights from bidirectional Mendelian randomization and genomic data analysis.

ABSTRACT: Constipation currently affects approximately 15% of the global population, and contemporary lifestyles are increasing its incidence every year. A significant number of individuals with constipation also experience ileus, a common surgical emergency known for its sudden onset and rapid progression. However, the intricate dynamics of the relationship between constipation and ileus are not well understood. This study aimed to elucidate the causal relationship and underlying mechanisms of constipation and ileus, thereby advancing our understanding of their interconnections. A bidirectional 2-sample Mendelian randomization (MR) analysis was performed using the IEU OpenGWAS database. Single nucleotide polymorphisms were used as instrumental variables to determine the causative association betwee

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC11835126 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature