A Closed Circulation Langendorff Heart Perfusion Method for Cardiac Drug Screening.

ABSTRACT: Cardiovascular diseases represent an economic burden for health systems accounting for substantial morbidity and mortality worldwide. Despite timely and costly efforts in drug development, the cardiovascular safety and efficacy of the drugs are not always fully achieved. These lead to the drugs' withdrawal with adverse cardiac effects from the market or in the late stages of drug development. There is a growing need for a cost-effective drug screening assay to rapidly detect potential acute drug cardiotoxicity. The Langendorff isolated heart perfusion technique, which provides cardiac hemodynamic parameters (e.g., contractile function and heart rate), has become a powerful approach in the early drug discovery phase to overcome drawbacks in the drug candidate's identification. However, trad

SUBMITTER: Deflers C 

PROVIDER: S-EPMC11835219 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature