AOP-networkFinder-a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki.

ABSTRACT:

Motivation

The Adverse Outcome Pathways (AOP)-Wiki, a knowledge database for AOPs, requires an efficient way to present an overview of its content for the reconstruction of networks by experts in a given domain. We have developed the AOP-networkFinder, a user-friendly tool that retrieves AOPs of interest, allows network generation and cleaning, and finally visualizes networks built around the retrieved AOPs. Our tool constructs AOP networks by connecting AOPs that use the same Key Events (KEs) in a versatile but controlled manner. Genes related to these KEs are also displayed. The constructed networks can then be exported as images or to Cytoscape for further fine-tuning and statistical analysis.

Results

The AOP-networkFinder allows users to comprehensively identify relation

SUBMITTER: Yarar N 

PROVIDER: S-EPMC11835234 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature