Functionally distinct pericyte subsets differently regulate amyloid-β deposition in patients with Alzheimer's disease.

ABSTRACT: Although the concept that the blood-brain barrier (BBB) plays an important role in the etiology and pathogenesis of Alzheimer's disease (AD) has become increasingly accepted, little is known yet about how it actually contributes. We and others have recently identified a novel functionally distinct subset of BBB pericytes (PCs). In the present study, we sought to determine whether these PC subsets differentially contribute to AD-associated pathologies by immunohistochemistry and amyloid beta (Aβ) peptidomics. We demonstrated that a disease-associated PC subset (PC2) expanded in AD patients compared to age-matched, cognitively unimpaired controls. Surprisingly, we found that this increase in the percentage of PC2 (%PC2) was correlated negatively with BBB breakdown in AD patients, unlike in n

SUBMITTER: Bohannon DG 

PROVIDER: S-EPMC11835444 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature