Myocardial Fibroblast Activation After Acute Myocardial Infarction: A Positron Emission Tomography and Magnetic Resonance Study.

ABSTRACT:

Background

Myocardial fibrosis is a key healing response after myocardial infarction driven by activated fibroblasts. Gallium-68-labeled fibroblast activation protein inhibitor ([⁶⁸Ga]-FAPI) is a novel positron-emitting radiotracer that binds activated fibroblasts.

Objectives

The aim of this study was to investigate the intensity, distribution, and time-course of fibroblast activation after acute myocardial infarction.

Methods

A total of 40 patients with acute myocardial infarction underwent hybrid [⁶⁸Ga]FAPI-46 positron emission tomography and cardiac magnetic resonance and were compared with matched control subjects (n = 19) and those with chronic (>2 years) myocardial infarction (n = 20). Intensity of [⁶⁸Ga]FAPI-46 uptake was quanti

SUBMITTER: Barton AK 

PROVIDER: S-EPMC11835506 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature