Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course.

ABSTRACT:

Background

Earlier identification of high coronary artery disease (CAD) risk individuals may enable more effective prevention strategies. However, existing 10-year risk frameworks are ineffective at earlier identification. We sought to understand how the variable importance of genomic and clinical factors across life stages may significantly improve lifelong CAD event prediction.

Methods

A longitudinal study was performed using data from 2 cohort studies: the FOS (Framingham Offspring Study) with 3588 participants aged 19 to 57 years and the UKB (UK Biobank) with 327 837 participants aged 40 years to 70 years. A total of 134 765 and 3 831 734 person-time years were observed in FOS and UKB, respectively. Hazard ratios for CAD were calculated for polygenic risk score (PRS) and

SUBMITTER: Urbut SM 

PROVIDER: S-EPMC11835529 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature