Impact of Prior Metformin Use on Stroke Outcomes: A Systematic Review and Updated Meta-Analysis.

ABSTRACT:

Background

Metformin is a commonly prescribed oral hypoglycemic agent for diabetic patients. Its effect in reducing the incidence of stroke has already been proven. We aimed to explore the impact of prior metformin use on stroke outcomes.

Methods

The Web of Science, PubMed, Embase, and Cochrane Library were searched to identify relevant studies involving stroke patients with a history of metformin use and comparing them to non-metformin users. We analyzed the following outcomes: modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), mortality, or length of hospitalization.

Results

Eleven studies, with 13,825 participants, were included. The metformin group showed higher favorable mRS 0 - 2 than the non-metformin group (risk ratio (RR) = 1.14,

SUBMITTER: Elgenidy A 

PROVIDER: S-EPMC11835556 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature