Functional poly(ether-ketone-ketone) composite scaffold with enhanced cell-material interaction, anti-inflammatory and osteogenesis for facilitating osteointegration and bone regeneration.

ABSTRACT: Bone defects resulting from trauma or disease remain a significant challenge in clinical practice, often requiring prolonged treatment. Poly(ether-ketone-ketone) (PEKK) is a commonly used implant material due to its excellent biocompatibility and mechanical properties, which are similar to those of bone. However, its biological inertness leads to poor anti-inflammatory and osteointegration properties, significantly hindering the bone repair process. In this study, a cryogel filled - PEKK/bioglass (BG) composite scaffold (SPBC) was prepared via 3D printing to provide immunomodulatory and bone integration performance. Compared with untreated PEKK, SPBC exhibited significant enhancements in surface properties, including higher hydrophilicity and roughness. Additionally, SPBC enhanced t

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11835654 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature