Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition.

ABSTRACT: The present study aimed to synthesize metal-doped magnesium oxide (MgO) nanoparticles to drastically reduce polydispersity and stabilize them with generation 5 of poly(amidoamine) (G5 PAMAM) dendrimers to assess their antidiabetic properties via controlled release. Zinc and silver metals were selected as dopants due to their ionic radius (0.74 Å and 1.16 Å, respectively) for MgO crystal defect reduction (ionic radii - 0.72 Å), allowing for the comparison of the dopants' effect on the nanoparticles' properties. Later, the resultant nanoparticles were formulated into G5 PAMAM dendrimers, and their amylase inhibition was evaluated and compared with that of non-formulated samples. The results showed that the addition of dopants led to smaller, more stable, and slightly monodispersed spherical,

SUBMITTER: Jeevanandam J 

PROVIDER: S-EPMC11835657 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature