Inflammation and endothelial gene polymorphism are associated with ischemic stroke.

ABSTRACT:

Aim

Evaluate the correlation between ischemic stroke and genetic variations related to inflammation and endothelial function.

Methods

This was a multicenter cross-sectional research conducted in southwestern China. Residents aged ≥40 years voluntarily join in the face-to-face survey in 8 communities. 2,377 participants were at high risk of stroke, of which 429 had a previous history of ischemic stroke. We selected the 429 ischemic stroke patients as the research subjects, and adopted a 1:1 matching method to select 429 healthy people with a 2-year age difference and the same gender and hypertension as the control group. We detected genotypes of 19 variants in 10 genes related to inflammation and endothelial function. Analyze gene-gene interaction through generalized multifac

SUBMITTER: Chen W 

PROVIDER: S-EPMC11835671 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature