Low transthyretin is associated with the poor prognosis of colorectal cancer.

ABSTRACT:

Objective

To determine whether transthyretin (TTR) influences the prognosis of patients with colorectal cancers and establish a predictive model based on TTR.

Methods

Between January 2013 and February 2019, the clinical data of 1322 CRC patients aged from 18 years to 80 years who underwent surgical treatment were retrospectively analyzed. The preoperative TTR level, clinicopathological data, and follow-up data were recorded. The X-tile program was used to determine the optimal cut-off value. Cox proportional hazard regression analysis was conducted to evaluate the correlation between the TTR and the cumulative incidence of cancer-specific survival (CSS). Nomograms were then developed to predict CSS. Furthermore, an additional cohort of 377 CRC patients enrolled between Janua

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11835676 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature