Intratumoral and peritumoral radiomics using multi-phase contrast-enhanced CT for diagnosis of renal oncocytoma and chromophobe renal cell carcinoma: a multicenter retrospective study.

ABSTRACT:

Purpose

To construct diagnostic models that distinguish renal oncocytoma (RO) from chromophobe renal cell carcinoma (CRCC) using intratumoral and peritumoral radiomic features from the corticomedullary phase (CMP) and nephrographic phase (NP) of computed tomography, and compare model results with manual and radiological results.

Methods

The RO and CRCC cases from five centers were split into a training set (70%) and a validation set (30%). CMP and NP intratumoral and peritumoral (1-3 mm) radiomic features were extracted. Segmentation was performed by radiologists and software. Features with high intraclass correlation coefficients (ICC>0.75) were selected through univariate analysis, followed by the LASSO method to determine the final features for the SVM model. All images w

SUBMITTER: Ye Y 

PROVIDER: S-EPMC11835681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature