Risk factors for fluorouracil-induced cardiotoxicity in patients with gastrointestinal tumor.

ABSTRACT:

Objective

To explore the risk factors for cardiotoxicity in patients with gastrointestinal (GI) tumors treated with fluorouracil drugs.

Methods

This study included patients with GI tumors who received fluorouracil at our hospital between January 2018 and April 2022. The demographic and clinical characteristics were collected. The risk factors associated with the cardiotoxicity of fluorouracil were explored using multivariable logistic regression.

Results

A total of 300 patients were finally included and divided into the cardiotoxicity (n = 81) and non-cardiotoxicity groups (n = 219). The occurrence of fluorouracil-induced cardiotoxicity was higher in patients with hypertension, hyperlipidemia, diabetes mellitus, older age, those treated with capecitabine

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11835890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature