Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury.

ABSTRACT:

Background

Spinal cord injury (SCI) poses a substantial challenge in contemporary medicine, significantly impacting patients and society. Emerging research highlights a strong association between SCI and chronic pain, yet the molecular mechanisms remain poorly understood. To address this, we conducted bioinformatics and systems biology analyses to identify molecular biomarkers and pathways that link SCI to chronic pain. This study aims to elucidate these mechanisms and identify potential therapeutic targets.

Methods

Through analysis of the GSE151371 and GSE177034 databases, we identified differentially expressed genes (DEGs) linked to SCI and chronic pain. This analysis uncovered shared pathways, proteins, transcription factor networks, hub genes, and potential therapeutic d

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11835904 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature