Serological determination of Trypanosoma cruzi in northern region of the State of Mexico.

ABSTRACT: Chagas disease, caused by Trypanosoma cruzi, remains a significant public health problem in Mexico, particularly challenging to diagnose during its chronic phase, due to low parasitemia and the complex immune response. According to the Pan American Health Organization, no single test is sufficiently sensitive or specific to reliably detect chronic Chagas disease, requiring the use of multiple serological methods when results are inconclusive. This study aimed to assess the seroprevalence of Chagas disease in the largely uncharted municipalities of the North of State of Mexico. A total of 250 serum samples from 17 municipalities were analyzed using a comprehensive approach involving three serological tests: the BIO-CHAGAS commercial kit (MEXLAB®), an ELISA test with antigens derived from an

SUBMITTER: Padilla-Valdez JM 

PROVIDER: S-EPMC11835914 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature