Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.

ABSTRACT:

Objectives

Neuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.

Methods

A systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. An anisotropic effect-size signed differential mapping (AES-SDM)-based meta-analysis was carried out to report the results and perform a multimodal analysis.

Results

A total of 20 publications reporting on 24 experiments in this meta-analysis. The ReHo meta-an

SUBMITTER: Chen X 

PROVIDER: S-EPMC11836031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature