<i>In vivo</i> confocal microscopic study of cornea verticillata and limbus deposits in patients with Fabry disease.

ABSTRACT:

Purpose

This study was aimed to investigate the microstructure characteristics of cornea verticillata and limbus deposits in patients with Fabry disease (FD) using in vivo confocal microscopy (IVCM).

Methods

A total of 60 eyes from 30 patients diagnosed with FD were examined and compared with 36 eyes from 18 healthy controls in this prospective, cross-sectional, controlled, single-center study. The initial assessment of cornea verticillata (CV) was conducted using slit-lamp microscopy. Subsequently, IVCM was performed to assess deposits in the corneal and limbal epithelium. We compared the differences between the sexes (heterozygous and hemizygous) and phenotypes (classical and non-classical).

Results

The epithelial deposit detection rate with IVCM was statisti

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11836033 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature