Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention.

ABSTRACT: Observational studies have linked uric acid (UA) levels and kidney disease to amino acid homeostasis, but the causal relationship is unclear. This study aims to determine if elevated UA affects amino acid levels and whether amino acids mediate this relationship, focusing on the causal links between UA, circulating amino acids, and kidney disease.

Methods

This study utilized Uox-KO mice as a hyperuricemia model, assessed renal injury through blood biochemistry and pathology, analyzed serum amino acid changes via targeted amino acidomics, and employed Mendelian randomization to investigate the causal links between uric acid, amino acids, and renal disease.

Results

Hyperuricemia Uox-KO mice have significantly higher serum UA and renal impairment markers, with histopathological a

SUBMITTER: Sheng Q 

PROVIDER: S-EPMC11836093 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature