Reduced temporal variability of cortical excitation/inhibition ratio in schizophrenia.

ABSTRACT: Altered neural excitation/inhibition (E/I) balance has long been suspected as a potential underlying cause for clinical symptoms in schizophrenia (SZ). Recent methodological advancements linking the spectral slope (β) of neurophysiological recordings - such as them electroencephalogram (EEG) - to E/I ratio provided much-needed tools to better understand this plausible relationship. Importantly, most approaches treat E/I ratio as a stationary feature in a single scaling range. On the other hand, previous research indicates that this property might change over time, as well as it can express different characteristics in low- and high-frequency regimes. In line, in this study we analyzed resting-state EEG recordings from 30 patients with SZ and 31 healthy controls (HC) and characterized E/I r

SUBMITTER: Racz FS 

PROVIDER: S-EPMC11836122 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature