Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not.

ABSTRACT: The objective of the study was to determine the specific roles of decorin and biglycan in the early and late phases of tendon healing in aged mice. Aged (300 day-old) female wildtype (WT), Dcn^flox/flox (I-Dcn^-/-), Bgn^flox/flox (I-Bgn^-/-), and compound Dcn^flox/flox/Bgn^flox/flox (I-Dcn^-/-/Bgn^-/-) mice with a tamoxifen (TM) inducible Cre underwent a bilateral patellar tendon injury (PT). Cre excision of the conditional alleles was induced at 5 days (samples collected at 3 and 6 weeks) or 21 days post-injury (samples collected at 6 weeks). Scar tissue area, collagen architecture, gene expression and mechanical properties were assessed during re-establishment of tendon architecture after injury. Fibril diame

SUBMITTER: Darrieutort-Laffite C 

PROVIDER: S-EPMC11836163 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature