External validation of the MAGNIFI-CD index in patients with complex perianal fistulising Crohn's disease.

ABSTRACT:

Background

There is an increasing need for objective treatment monitoring in perianal fistulising Crohn's disease (pfCD). Therefore, the magnetic resonance novel index for fistula imaging in CD (MAGNIFI-CD) index has been designed and internally validated on the ADMIRE-CD trial cohort. The aim of this study was to externally validate the MAGNIFI-CD index to monitor response to medical and surgical treatment regimens in pfCD.

Methods

A retrospective longitudinal cohort was established of consecutive patients with complex pfCD treated with surgical and/or medical therapy and a baseline and follow-up MRI between January 2007 and May 2021. The MAGNIFI-CD index was scored by two independent, abdominal radiologists blinded for time points and clinical outcomes. Responsiveness, rel

SUBMITTER: Beek KJ 

PROVIDER: S-EPMC11836172 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature