Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.

ABSTRACT: Antimicrobial resistance (AMR) is a pressing global health issue, intensified by the spread of resistant pathogens like Klebsiella pneumoniae (K. pneumoniae), which frequently causes hospital-acquired infections. This study focuses on a multidrug-resistant K. pneumoniae sequence type (ST) 656 strain, isolated from canal water in Bangladesh. Whole-genome sequencing and comparative genomic analysis revealed extensive resistance mechanisms and genetic elements underlying its adaptability. The strain exhibited resistance to colistin and multiple β-lactam antibiotics, containing key resistance genes such as mcr8.1, bla_LAP-2, bla_TEM-1, bla_SHV-11 and bla_OXA-1, alongside genes for copper, zinc, and silver resistance, indicating survival capability in met

SUBMITTER: Mondol SM 

PROVIDER: S-EPMC11836182 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature