Immediate Irradiation Induced Cerebral Water and Hemodynamic Response in Whole Brain Radiotherapy.

ABSTRACT:

Purpose

Effects of clinical radiotherapy are often studied between or after irradiations. The current study's aim was to monitor an immediate irradiation response in cerebral water and hemodynamics in patients treated with whole brain radiotherapy (WBRT) and to assess the response's individuality.

Methods

We used functional near-infrared spectroscopy (fNIRS) to monitor changes in cerebral water, oxyhemoglobin (HbO), and deoxyhemoglobin (HbR) during the irradiation of 31 patients (age 69.3 ± 12.5 years, 16 females) receiving WBRT. The radiation dose delivered to a patient during a single measurement was 4 Gy (total dose of 20 Gy in five fractions) for most patients and 3 Gy (total dose of 30 Gy in ten fractions) for three patients.

Results

106 patient recordings were a

SUBMITTER: Miettinen H 

PROVIDER: S-EPMC11836184 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature