Prioritization of Lipid Metabolism Targets for the Diagnosis and Treatment of Cardiovascular Diseases.

ABSTRACT: Background: Cardiovascular diseases (CVD) are a major global health issue strongly associated with altered lipid metabolism. However, lipid metabolism-related pharmacological targets remain limited, leaving the therapeutic challenge of residual lipid-associated cardiovascular risk. The purpose of this study is to identify potentially novel lipid metabolism-related genes by systematic genomic and phenomics analysis, with an aim to discovering potentially new therapeutic targets and diagnosis biomarkers for CVD. Methods: In this study, we conducted a comprehensive and multidimensional evaluation of 881 lipid metabolism-related genes. Using genome-wide association study (GWAS)-based mendelian randomization (MR) causal inference methods, we screened for genes causally linked to t

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11836198 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature