Preoperative prediction of diffuse glioma type and grade in adults: a gadolinium-free MRI-based decision tree.

ABSTRACT:

Objectives

To develop a gadolinium-free MRI-based diagnosis prediction decision tree (DPDT) for adult-type diffuse gliomas and to assess the added value of gadolinium-based contrast agent (GBCA) enhanced images.

Materials and methods

This study included preoperative grade 2-4 adult-type diffuse gliomas (World Health Organization 2021) scanned between 2010 and 2021. The DPDT, incorporating eleven GBCA-free MRI features, was developed using 18% of the dataset based on consensus readings. Diagnosis predictions involved grade (grade 2 vs. grade 3/4) and molecular status (isocitrate dehydrogenase (IDH) and 1p/19q). GBCA-free diagnosis was predicted using DPDT, while GBCA-enhanced diagnosis included post-contrast images. The accuracy of these predictions was assessed by three rate

SUBMITTER: Azizova A 

PROVIDER: S-EPMC11836213 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature