Genetic insights into the shared molecular mechanisms of Crohn's disease and breast cancer: a Mendelian randomization and deep learning approach.

ABSTRACT: The objective of this study was to explore the potential genetic link between Crohn's disease and breast cancer, with a focus on identifying druggable genes that may have therapeutic relevance. We assessed the causal relationship between these diseases through Mendelian randomization and investigated gene-drug interactions using computational predictions. This study sought to identify common genetic pathways possibly involved in immune responses and cancer progression, providing a foundation for future targeted treatment research. The dataset comprises single nucleotide polymorphisms used as instrumental variables for Crohn's disease, analyzed to explore their possible impact on breast cancer risk. Gene ontology and pathway enrichment analyses were conducted to identify genes shared betwee

SUBMITTER: Wang ZZ 

PROVIDER: S-EPMC11836263 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature