MiRNA profiling of hiPSC-derived neurons from monozygotic twins discordant for schizophrenia.

ABSTRACT: Schizophrenia is a complex developmental disorder whose molecular mechanisms are not fully understood. The developmental course of schizophrenia can be modeled with human induced pluripotent stem cell (hiPSC) -derived brain cells that carry patient-specific genetic risk factors for the disorder. Although transcriptomic characterization of the patient-derived cells is a standard procedure, microRNA (miRNA) profiling is less frequently performed. To investigate the role of miRNAs in transcriptomic regulation in schizophrenia, we performed miRNA sequencing for hiPSC-derived neurons from five monozygotic twin pairs discordant for schizophrenia and six controls (CTR). We compared the miRNA expression to differentially expressed genes (DEGs) reported for the same cells in our earlier work. We fo

SUBMITTER: Rasanen N 

PROVIDER: S-EPMC11836399 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature