Muscle selection and dosing in patients undergoing treatment with abobotulinumtoxinA for lower limb spasticity in real-world practice.

ABSTRACT:

Objective

Describe abobotulinumtoxinA (aboBoNT-A) dosing parameters in the real-world management of lower limb spasticity (LLS).

Methods

Prospective, observational study (NCT0​4050527) following ambulatory adults with unilateral LLS treated with aboBoNT-A.

Results

The effectiveness population included 384 adults with LLS. Across the study, total lower limb doses were higher in patients who received only lower limb injections (n = 131, median 771U) than those who also received ≥ 1 upper limb injection (n = 253, 567U). Total doses increased over subsequent cycles in both subgroups. Six muscles (gastrocnemius medial and lateral heads, soleus muscle, tibialis posterior, flexor digitorum longus, and flexor hallucis longus) were identified as the main targets for the treatm

SUBMITTER: Zorowitz RD 

PROVIDER: S-EPMC11836465 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature