Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study.

ABSTRACT:

Background

Fluoroquinolones (FQs) are commonly used to treat urinary tract infections (UTIs), but some studies have suggested they may increase the risk of aortic aneurysm or dissection (AA/AD). However, no large-scale international study has thoroughly assessed this risk.

Methods

A retrospective cohort study was conducted using a large, distributed network analysis across 14 databases from 5 countries (United States, South Korea, Japan, Taiwan, and Australia). The study included 13,588,837 patients aged 35 or older who initiated systemic fluoroquinolones (FQs) or comparable antibiotics (trimethoprim with or without sulfamethoxazole [TMP] or cephalosporins [CPHs]) for UTI treatment in the outpatient setting between JAN 01, 2010 and DEC 31, 2019. Patients were included if at

SUBMITTER: Janetzki JL 

PROVIDER: S-EPMC11836508 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature