Prognostic Impact of Stimulator of Interferon Genes Expression in Triple Negative Breast Cancer.

ABSTRACT:

Background

Patients with triple negative breast cancer (TNBC) who have a poor response to neoadjuvant chemotherapy (NAC) have worse survival and new treatment strategies need to be developed. TNBC is considered a subtype in which the cyclic GMP-AMP synthase (cGAS) is linked to the stimulator of interferon genes (STING) pathway, an innate immune response that recognizes cytosolic nucleic acid components, is activated when DNA damage occurs, and is attracting attention as a new therapeutic target.

Methods

Patients with TNBC who underwent surgery following NAC and for whom pre- and post-treatment tissue specimens were available were enrolled in this study. To examine the association of STING expression with immune profiles and prognosis, STING, cGAS, CD8, and programmed cell de

SUBMITTER: Maeda T 

PROVIDER: S-EPMC11836529 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature