Evaluation of T-cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects.

ABSTRACT: The group of patients with DNA-repair-defects increases susceptibility to infections due to impaired repertoire diversity. In this context, we aimed to investigate the TCRvβ-repertoire by flow cytometric analysis and its correlation with clinical entities in a group of IEI patients with DNA repair defects. Peripheral lymphocyte subset and TCRvβ-repertoire analyses were performed by flow cytometric analysis. The aim was to explore the changing TCR-Vβ-repertoire that can predict some clinical entities by investigating the repertoire using flow-cytometric-analysis-based TCR-Vβ and its interaction with clinical entities in a group of IEI patients with DNA repair defects. TCR-repertoire of the patients with DNA-repair-defects and healthy controls was analysed with flow-cytometer. The potential

SUBMITTER: Karaaslan BG 

PROVIDER: S-EPMC11836546 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature