Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors.

ABSTRACT:

Rationale

Flavors can alter the orosensory properties of tobacco products. Specifically, flavors can serve as an oral cue for smokeless tobacco products.

Objectives

We aimed to investigate the impact of oral vanillin, the principal chemical of vanilla flavor in tobacco products, on nicotine's taste, and nicotine choice, intake, and seeking behaviors.

Methods

Experiments were performed in young adult Sprague Dawley rats. We employed a two-bottle free-choice test (2BC) to measure the preference for different concentrations of vanillin and its effect on nicotine preference. To explore the long-term effects of early exposure to sweetened vanillin, we utilized a combined 2BC and intraoral self-administration (IOSA) model. We assessed the nicotine taking and seeking behavio

SUBMITTER: Bagdas D 

PROVIDER: S-EPMC11836642 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature