Plasma endothelin-1 levels in patients with rotator cuff tear: a case-control study.

ABSTRACT:

Background

Several recent studies have demonstrated that the alteration of tendon microcirculation is one of the main causes of rotator cuff degeneration and tear. The aim of this study was to assess if patients with a rotator cuff tear (RCT) exhibit altered levels of endothelin-1 (ET-1), a powerful vasoconstrictor that could play a key role in the pathogenesis of RCTs, as well as in other tendon structures.

Methods

A case-control study was conducted on 103 participants, divided into 60 cases and 43 controls. A sample of peripheral venous blood was collected from each participant. Each sample underwent centrifugation to obtain plasma, which was then analyzed using a specific enzyme-linked immunosorbent assay (ELISA) kit for human ET-1.

Results

A total of 54 cases and

SUBMITTER: Gumina S 

PROVIDER: S-EPMC11836734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature