De-escalation of axillary treatment in early breast cancer-a narrative review of current trials.

ABSTRACT:

Background and objective

In the era of de-escalation and minimally invasive locoregional treatments across many fields of surgical oncology, the treatment of the axilla in breast cancer has garnered significant interest. While the knowledge of axillary lymph node involvement is crucial for multidisciplinary management, the surgical approach to the axillary basin can have potential disadvantages that may impact the quality of life. The objective of this narrative review is to examine studies about de-escalation of axillary treatment in various clinical scenarios, namely the settings of upfront surgery and neoadjuvant systemic treatments. Moreover, trials investigating omission of axillary surgery were examined.

Methods

As of July 2024, a comprehensive literature search, compi

SUBMITTER: Fancellu A 

PROVIDER: S-EPMC11836741 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature