Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial.

ABSTRACT:

Importance

Persisting or new thrombi in the distal arteries and the microcirculation have been reported to limit the benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete to complete reperfusion by thrombectomy improves outcomes among patients with ischemic stroke due to large vessel occlusion.

Objective

To assess the efficacy and adverse events of intra-arterial urokinase after near-complete to complete reperfusion by thrombectomy for acute ischemic stroke due to large vessel occlusion.

Design, setting, and participants

This investigator-initiated, randomized, open-label, blinded-end point trial was implemented at 35 hospitals in China, en

SUBMITTER: Liu C 

PROVIDER: S-EPMC11836763 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature