Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue.

ABSTRACT:

Background

Oncolytic viruses are promising tools for immune stimulatory gene therapy of cancer, but their clinical effect on solid tumors have so far been limited. Transduction of the target tumor cells is limited by both extracellular matrix that blocks viral spread within the solid tumor tissue and electrostatic forces that inhibit virus from binding its entry receptor on the cell surface. The enzymes hyaluronidase and collagenase and the polycations diethylaminoethyl (DEAE)-dextran, branched Polyethylenimine (PEI) and protamine sulfate have previously shown potential to improve gene transfer in different forms of viral gene therapy, since they may help the virus to overcome these barriers. In this study, we compared the transduction-enhancing p

SUBMITTER: Yngve E 

PROVIDER: S-EPMC11836772 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature