Risk of Alzheimer's Disease and Related Dementias in Persons with Glaucoma: A National Cohort Study.

ABSTRACT:

Purpose

Glaucoma is a heterogeneous group of optic neuropathies that potentially may be associated with other cerebral neurodegenerative processes leading to dementia. However, prior studies have been inconsistent. We examined dementia risks after glaucoma diagnosis in a large population-based cohort.

Design

National matched cohort study.

Participants

A total of 324 730 persons diagnosed with glaucoma during 1995-2017 in Sweden and 3 247 300 age- and sex-matched population-based controls without prior dementia.

Methods

Cox regression was used to compute hazard ratios (HRs) for Alzheimer's disease (AD), vascular dementia (VaD), and all-cause dementia in persons with glaucoma compared with controls, adjusting for sociodemographic factors and comorbidities.

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SUBMITTER: Crump C 

PROVIDER: S-EPMC11836936 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature