CSF IL-6, GDF-15, GFAP and NfL levels in early Alzheimer disease: a pilot study.

ABSTRACT:

Background

Despite their potential usefulness as biomarkers, no study has investigated the interactions between cerebrospinal fluid (CSF) changes of neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), growth differentiation factor 15 (GDF-15), transactive response DNA binding protein (TDP-43) and interleukin-6 (IL-6) and the core AD CSF biomarkers in the same cohort of AD patients.

Objectives

The aim of this pilot study is to evaluate the CSF levels of these analytes in patients with AD and assess their clinical relevance in this neurological condition.

Design

Cross-sectional study.

Methods

We assessed the levels of NfL, GFAP, GDF-15, TDP-43 and IL-6 in the CSF samples of 52 early AD patients and evaluated their partial reciprocal correlati

SUBMITTER: Plantone D 

PROVIDER: S-EPMC11837071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature