Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing.

ABSTRACT: Autophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components. A decline in autophagic activity is associated with aging, and contributes to the development of various age-associated pathologies, including cancer. There is an ongoing need to develop chemotherapeutic agents to improve morbidity and mortality for those diagnosed with cancer, as well as to decrease the cost of cancer care. Autophagic programs are altered in cancer cells to support survival in genetically and metabolically unstable environments, making autophagy an attractive target for new chemotherapy. Antiretroviral drugs, which have dramatically increased the

SUBMITTER: Cheney L 

PROVIDER: S-EPMC11837255 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature