The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction.

ABSTRACT:

Background

Heart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and the severity/prognosis of HFrEF.

Methods

A retrospective analysis was conducted on 105 HFrEF patients and 86 healthy volunteers. RT-qPCR was used for the detection of serum hsa-miR-21-5p levels. Whether serum hsa-miR-21-5p expression correlated to cardiac function and hemodynamic indicators was evaluated using Spearman correlation analysis. Receiver operating characteristic and Kaplan-Meier analyses were implemented to evaluate the predictive significance of serum hsa-miR-21-5p for cardiova

SUBMITTER: Wang L 

PROVIDER: S-EPMC11837298 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature