Bioelectric profiling of Rickettsia montanensis in Vero cells utilizing dielectrophoresis.

ABSTRACT: Rickettsia is an intracellular bacteria transmitted to humans through ticks, lice, fleas, or their feces, causing acute symptoms such as fever, headache, rashes, and muscle aches. Detecting rickettsial diseases is challenging due to limitations in current methods such as negative results, low sensitivity, and high cost. These limitations highlight the need for improved detection methods. Dielectrophoresis (DEP) offers a promising alternative to develop a point-of-care economical, label-free, and sensitive diagnostic tool. By exposing cells to non-uniform electric fields one can measure the electrical properties of the cells which are different and unique based on the cell type. By comparing the dielectric profiles of healthy and infected cells, DEP could be utilized to design a rapid, cost

SUBMITTER: Doost NF 

PROVIDER: S-EPMC11837300 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature