Epileptogenic zone characteristics determine effectiveness of electrical transcranial stimulation in epilepsy treatment.

ABSTRACT: Transcranial direct current stimulation shows promise as a non-invasive therapeutic method for patients with focal drug-resistant epilepsy. However, there is considerable variability in individual responses to transcranial direct current stimulation, and the factors influencing treatment effectiveness in targeted regions are not well understood. We aimed to assess how the extent and depth of the epileptogenic zone and associated networks impact patient responses to transcranial direct current stimulation therapy. We conducted a retrospective analysis of stereoelectroencephalography data from 23 patients participating in a personalized multichannel transcranial direct current stimulation protocol. We evaluated the extent and depth of the epileptogenic zone network, propagation zone network,

SUBMITTER: Daoud M 

PROVIDER: S-EPMC11837341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature