GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer.

ABSTRACT:

Background

Brain metastasis (BrM) poses a significant challenge to the prognosis and quality of life for patients with non-small cell lung cancer (NSCLC). Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system (CNS), has been implicated in the progression of various tumors. However, its potential role in BrM of NSCLC and the underlying mechanisms remain largely unexplored.

Methods

A multi-omics approach combined with in vivo and in vitro experiments identified GABA as a key target in BrM of NSCLC. Functional and mechanistic studies were conducted to investigate how GABA mediates brain metastasis through the activation of the NF-κB pathway.

Results

GABA levels were significantly elevated in both cells and serum of patients with NSC

SUBMITTER: Xie M 

PROVIDER: S-EPMC11837350 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature