The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity.

ABSTRACT:

Background

Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer's disease (AD). Given the imminent use of certain blood biomarkers in the routine diagnostic work-up of patients with suspected AD, knowledge on the potential impact of comorbidities on the utility of blood biomarkers is important. We aimed to evaluate the association between kidney function, assessed through estimated glomerular filtration rate (eGFR) calculated from plasma creatinine and AD blood biomarkers, as well as their influence over predicting Aβ-positivity.

Methods

We included 242 participants from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort, comprising cognitively unimpaired individuals (CU; n = 124), mild cogni

SUBMITTER: Arslan B 

PROVIDER: S-EPMC11837363 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature