Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study.

ABSTRACT:

Background

This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings.

Methods

249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, and plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva and Lausanne Memory Clinics. Mann-Whitney U tests investigated sex differences in clinical and biomarker data. Linear regression models estimated the moderating effect of sex on the relationship between biomarkers and cognitive performance and decline. Sex differences in cognitive decline were further evaluated using longitudinal linear mixed-effect models with three-way interaction effects.

Results

Women a

SUBMITTER: Boccalini C 

PROVIDER: S-EPMC11837373 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature