The impact of insecticide decay on the rate of insecticide resistance evolution for monotherapies and mixtures.

ABSTRACT:

Background

The problem of insecticide decay following their deployment in public health applications is frequently highlighted as an issue for sustained disease control. There are additional concerns that it also increases selection for insecticide resistance. Despite these concerns insecticide decay is largely absent from models evaluating insecticide resistance management strategies.

Methodology

The impact of insecticide decay is investigated using a model which assumes a polygenic basis of insecticide resistance. Single generation evaluations are conducted that cover the insecticide efficacy and insecticide resistance space for insecticides when deployed as monotherapies or mixtures to mechanistically investigate how insecticide decay impacts selection for resistance. The

SUBMITTER: Hobbs NP 

PROVIDER: S-EPMC11837469 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature