Liposomal MRI probes containing encapsulated or amphiphilic Fe(III) coordination complexes.

ABSTRACT: Liposomes containing high-spin Fe(III) coordination complexes were prepared towards the production of T₁ MRI probes with improved relaxivity. The amphiphilic Fe(III) complexes were anchored into the liposome with two alkyl chains to give a coordination sphere containing mixed amide and hydroxypropyl pendant groups. The encapsulated complex contains a macrocyclic ligand with three phosphonate pendants, [Fe(NOTP)]^3-, which was chosen for its good aqueous solubility. Four types of MRI probes were prepared including those with intraliposomal Fe(III) complex (LipoA) alone, amphiphilic Fe(III) complex (LipoB), both intraliposomal and amphiphilic complex (LipoC) or micelles formed with amphiphilic complex. Water proton relaxivities r₁ and r

SUBMITTER: Chowdhury MSI 

PROVIDER: S-EPMC11837487 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature