Effects of vitamin B₁₂ supply on cellular processes of the facultative vitamin B₁₂ consumer <i>Vibrio campbellii</i>.

ABSTRACT: Vitamin B₁₂ (cobalamin, herein B₁₂) is a key cofactor for most organisms being involved in essential metabolic processes. In microbial communities, B₁₂ is often scarce, largely because only few prokaryotes can synthesize B₁₂ de novo and are thus considered B₁₂-prototrophs. B₁₂-auxotrophy is mostly manifested by the absence of the B₁₂-independent methionine synthase, MetE. Here, we focus on bacteria that we classified as facultative B₁₂ consumers as they encode both B₁₂-independent and -dependent (MetH) methionine synthases yet largely cannot synthesize B₁₂ de novo. The genus Vibrio belongs to this group, and our work shows that upon B₁₂ supply growth

SUBMITTER: Groon L-A 

PROVIDER: S-EPMC11837498 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature